منابع مشابه
Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol.
Adult neurogenesis is a newly considered form of plasticity that could contribute to brain dysfunction in psychiatric disease. Chronic alcoholism, a disease affecting over 8% of the adult population, produces cognitive impairments and decreased brain volumes, both of which are partially reversed during abstinence. Clinical data and animal models implicate the hippocampus, a region important in ...
متن کاملPersistent variations in neuronal DNA methylation following cocaine self-administration and protracted abstinence in mice
Continued vulnerability to relapse during abstinence is characteristic of cocaine addiction and suggests that drug-induced neuroadaptations persist during abstinence. However, the precise cellular and molecular attributes of these adaptations remain equivocal. One possibility is that cocaine self-administration leads to enduring changes in DNA methylation. To address this possibility, we isolat...
متن کاملLoss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence.
Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphe...
متن کاملConvergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence.
A major hypothesis in addiction research is that alcohol induces neuroadaptations in the mesolimbic dopamine (DA) system and that these neuroadaptations represent a key neurochemical event in compulsive drug use and relapse. Whether these neuroadaptations lead to a hypo- or hyperdopaminergic state during abstinence is a long-standing, unresolved debate among addiction researchers. The answer is...
متن کاملProtracted abstinence from distinct drugs of abuse shows regulation of a common gene network.
Addiction is a chronic brain disorder. Prolonged abstinence from drugs of abuse involves dysphoria, high stress responsiveness and craving. The neurobiology of drug abstinence, however, is poorly understood. We previously identified a unique set of hundred mu-opioid receptor-dependent genes in the extended amygdala, a key site for hedonic and stress processing in the brain. Here we examined the...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1849
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(01)43756-1